EFFECTIVENESS OF IODINOL IN COMBINATION WITH SUCCINIC ACID AT RISK OF DEVELOPING FATTY HEPATOSIS IN COWS

Abstract

In this report, we present the results of injecting an iodometabolic composition based on the well-known veterinary drug yodinol in combination with succinic acid during the predicted periods of risk of developing fatty hepatosis in lactating cows. The results of the post-slaughter examination indicate that fatty liver degeneration is detected in about 80% of culled cows. The main cause of fatty liver degeneration in lactating cows is the intensive involvement of the body's own fat reserves in the energy metabolism. With the intensive involvement of fats in the energy processes, some of them do not have time to be metabolized and are deposited in the liver cells, which leads to a liver coma and the death of cows. Theoretical basis for the application of iodotyrosines composition for the prevention of fatty liver was the experimental research of scientists of Institute of Biophysics on the assessment of the effectiveness of succinates activation energy metabolism. They found that succinic acid and its succinate salts increase the detoxification and metabolic activity of the liver tenfold. Exogenously administered succinic acid, even in absolutely low dosages, nevertheless provides an atypically high metabolic effect, in particular, to increase the oxygen consumption of liver cells by 60 times. According to the results of clinical trials, it was found that the injectable use of this composition provided a pronounced correction of pathobiochemical processes in high-yielding cows under conditions of intensive involvement of their own body lipids in energy processes. This had a positive impact on the health and safety of the cows.