EFFECT OF RECOMBINANT INTERFERON-TAU ON THE HORMONAL AND CYTOKINE PROFILE OF COWS IN THE EARLY PERIOD OF GESTATION

Abstract

The physiological processes of the early stages of pregnancy in cattle are determined by the level of production of progesterone, interferon-tau, and pro-inflammatory cytokines IL-2, TNF?, IFN-?, providing in adequate concentrations immune and trophic relationships between the mother's body and the developing embryo. The results of the research on the influence of the bovine recombinant interferon-tau-based drug «Tautin», in “Scientific and Production Center ProBioTech” LLC., on blood progesterone, on cortisol, on interleukin IL-2, on tumor necrosis factor - TNF?, on interferons -? and -tau, and on the insemination effectiveness, in the black-and-white Holstein cows, are presented. Injections of “Tautin” at the stage of placentation provide an increase in the progesterone-synthesizing function of the corpus luteum, modulation of the local production of the main mediators of the immune system - pro-inflammatory cytokines and guarantee the successful implantation of the embryo and its further physiological development. It is shown that three times injections of «Tautin» to cows during nidation and implantation of blastocyst provide the increase of luteal hormone synthesizing function of corpus luteum in comparison with intact animals by 21.5 %, concentration of cortisol in blood by 11.5%, interferon-tau by 36.9%, and decrease of production of proinflammatory cytokines: IL-2 by 24.5%, TNF? by 21.7%, and interferon ? by 28.5%. The effectiveness of artificial insemination of experimental cows was 74.1% at 37.8% in control group. Development of intrauterine embryo grow retardation syndrome has been reduced from 29.4% to 12.5%.