TOXICOLOGICAL CHARACTERISTICS OF THE DRUG HYPERICO

Authors

  • O. D. Sklyarov Federal State Institution “The Russian State Center for Quality and Standardization of Animal Drugs and Feed”
  • E. K. Rakhmatullin Federal State Budgetary Scientific Institution Federal Center for Toxicological, Radiation and Biological Safety”
  • O. V. Babicheva Federal State Institution “The Russian State Center for Quality and Standardization of Animal Drugs and Feed”
  • N. A. Litvinov Federal State Institution “The Russian State Center for Quality and Standardization of Animal Drugs and Feed”

DOI:

https://doi.org/10.31857/S2500208224040199

Keywords:

dyspepsia, toxicity, Hyperico, LD50, thiopental, red blood cells, hemoglobin, leukocytes, erythrocyte sedimentation rate (ESR)

Abstract

The article presents the results of a study of the toxicity of the drug Hyperico. It has been established that the drug is low-toxic and safe for animals with daily use. It does not provoke the development of pathological reactions. According to the classification of Hodge and Sterner (1943), Hyperico can be classified as toxicity class 6 – relatively harmless. The LD50 value of the drug after intragastric administration to white rats was ?36400 mg/kg, to mice – ?45400 mg/kg, irritation of the mucous membranes of the digestive tract was not observed. According to GOST 12.1.007.76, Hyperico belongs to the 4th hazard rating, that is low-hazard substances. Based on the results of the study, a reasonable conclusion can be made that Hyperico does not have a toxic effect on calves. There are no contraindications for conducting clinical trials of the drug Hyperico.

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Published

2024-08-15

Issue

No. 4 (2024): July-August

Section

ЗООТЕХНИЯ

How to Cite

Sklyarov, O. D., Rakhmatullin, E. K., Babicheva, O. V., & Litvinov, N. A. (2024). TOXICOLOGICAL CHARACTERISTICS OF THE DRUG HYPERICO. Vestnik of the Russian Agricultural Science, 4, 99-101. https://doi.org/10.31857/S2500208224040199