ANEMIC SYNDROME: CONDITION, PROBLEMS AND POSSIBLE APPROACHES TO INCREASING THE EFFECTIVENESS OF ANTI-ANEMIC THERAPY

Abstract

 The materials of this article reflect the problem of low effectiveness of antianemic therapy and propose an author's approach to solving it. Until recently, in medicine and veterinary medicine, the low effectiveness of antianemic therapy was traditionally explained by the low bioavailability of iron. At the same time, the question remained that energy is needed for the assimilation of iron. With a low energy potential of the body, the antianemic activity of iron preparations is sometimes close to placebo. Moreover, the use of iron preparations is often manifested by side reactions, in particular to the activation of free radical oxidation processes up to the death of animals. Based on the theoretical analysis of the development of energy metabolism failures, the prospect of using succinates to provide the body with fast energy is substantiated. As an illustrative example, the results of clinical studies on the inclusion of sodium succinate in the composition of pharmacopoeial Ferroglucine are presented.  During clinical experiments on calves with a complex symptom complex of hypotrophy, asthenia and anemia, it was found that the injectable use of succinate containing Ferroglucine provided a much more pronounced metabolic and antianemic effect compared with a pharmacopoeial drug.  This approach is new and deserves the attention of scientific researchers involved in the development of antianemic drugs, including the manufacturers of the drug Ferroglucine themselves for the specific use of the research results obtained.