PHARMACOLOGICAL CORRECTION OF HEPATOTOXICITY INDUCED BY KINMIKS

Abstract

Improper usage of pyrethroid pesticides, non-compliance with the rules of storage and transportation can lead to negative consequences (poisoning, allergic reactions, chronic disorders of body systems, death). In recent decades, the attention of scientists has been attracted by the problem of toxic damage to the liver by pesticides. Kinmiks is a pyrethroid insecticide, the active ingredient is beta-cypermethrin (50 g/l). Conducted complex experimental studies have shown that Kinmiks, when administered intragastrically to animals, provokes the development of pathological reactions and has a toxic effect on the liver. It was concluded that in the complex treatment of poisoning with pesticides containing ?-cypermethrin, the dipyroxime and pyridoxine hydrochloride should be used. For early diagnosis of pesticide poisoning the indicators of bilirubin, albumin, ALT, alkaline phosphatase and the ratio of ALT to alkaline phosphatase can be used as markers.